National Path Lab

Autoimmune & Inflammatory Risk

Autoimmune and inflammatory risk refers to the likelihood of developing a condition in which the immune system reacts abnormally against the body's own tissues, or produces excessive, persistent inflammation. This includes conditions such as rheumatoid arthritis, lupus, and a range of related disorders.

Autoimmune conditions often develop gradually, with early symptoms — joint pain, fatigue, skin changes — that can be subtle or mistaken for other, more common causes. Identifying autoimmune activity early allows treatment to begin before irreversible organ or joint damage occurs.

At National Path Lab (NPL), a comprehensive range of autoimmune and inflammatory marker testing is available to support early risk assessment.

Tests Available at NPL

C3 COMPLEMENT

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SAMPLE DAILY BY 7:00 PM REPORT ON SAME DAY

Rs. 1500

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C4 COMPLEMENT

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Rs. 1500

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RA (RHEUMATOID) FACTOR QUALITATIVE

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Rs. 350

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RA (RHEUMATOID) FACTOR QUANTITATIVE

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Rs. 700

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ANTI THYROID PEROXIDASE ANTIBODY; ANTI TPO

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Rs. 2200

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ANTI CYCLIC CITRULLINATED PEPTIDE; ANTI CCP

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Rs. 2800

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C-REACTIVE PROTEIN HIGH SENSITIVE; HSCRP

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SAMPLE DAILY BY 7:00 PM REPORT ON SAME DAY

Rs. 1650

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C-REACTIVE PROTEIN (CRP) QUANTITATIVE

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SAMPLE DAILY BY 7:00 PM REPORT ON SAME DAY

Rs. 800

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ERYTHROCYTE SEDIMENTATION RATE; ESR

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Rs. 150

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About Autoimmune & Inflammatory Risk

Who Is at Risk?

Autoimmune and inflammatory risk is shaped by both inherited and environmental factors:

Non-Modifiable Factors

Modifiable Factors

  • Family history of autoimmune disease

  • Smoking — a recognized risk factor for rheumatoid arthritis and other conditions

  • Sex — many autoimmune conditions are significantly more common in women

  • Certain environmental exposures and infections, in genetically susceptible individuals

  • Age of onset commonly between 20 and 50 for many autoimmune conditions

  • Chronic, unmanaged stress

  • Having one autoimmune condition modestly increases risk of developing another

  • Excessive UV/sun exposure, relevant to certain skin-related autoimmune conditions

Warning Signs You Shouldn't Ignore

  • Persistent joint pain, swelling, or morning stiffness lasting more than an hour

  • Unexplained, persistent fatigue

  • Recurrent low-grade fever

  • Unexplained skin rashes, particularly if light-sensitive

  • Persistent dry eyes or dry mouth

  • Unexplained hair loss

  • Recurrent, unexplained blood clots

Test

Clinical Relevance

ANA (Antinuclear Antibody)

An important initial screening test when systemic autoimmune disease is suspected.

CRP & ESR

General markers of inflammation, useful for assessing inflammatory activity.

Rheumatoid Factor (RF) & Anti-CCP

Relevant to evaluating possible rheumatoid arthritis.

Complement C3 & C4

Can provide useful information in selected autoimmune and immune-complex conditions.

Thyroid Antibodies (Anti-TPO)

Relevant given the overlap between autoimmune thyroid disease and other autoimmune conditions.

Related Packages

AUTOIMMUNE HEPATITIS PANEL 1

Test Includes
6 Tests

Rs. 12000

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AUTOIMMUNE / ARTHRITIS HEALTH CHECKUP PACKAGE

Test Includes
13 Tests

Rs. 5500

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AUTOIMMUNE INTERSTITIAL LUNG DISEASE (ILD) PANEL

Test Includes
5 Tests

Rs. 16000

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Frequently Asked Questions

ANA is useful in evaluating several systemic autoimmune and connective-tissue diseases, but it does not detect all autoimmune conditions and is not diagnostic on its own — it requires clinical correlation.
No, routine population screening is not generally recommended. Testing is most useful when guided by symptoms or a significant family history, rather than performed broadly without an indication.
Not entirely, since genetic predisposition plays a significant role, but modifiable factors such as smoking cessation may reduce risk or severity for certain conditions like rheumatoid arthritis.
No. ANA can be positive in several different conditions, and even in some healthy individuals. A positive result requires further evaluation and clinical correlation, not an automatic diagnosis.
Because many autoimmune conditions cause cumulative damage the longer they remain active — early treatment can prevent or significantly reduce irreversible joint, organ, or tissue damage.